IGF-1 LR3 research peptide — wholesale supply

For research use only · Not for human consumption · Not for veterinary use. This product is supplied for in-vitro research, analytical method development, and laboratory reference standard use only. Not approved for human or veterinary administration. Buyer is responsible for end-use classification in the destination jurisdiction.

Overview

IGF-1 LR3 is the long-arginine variant of insulin-like growth factor 1, an 83-amino-acid recombinant analogue of human IGF-1. The "LR3" designation refers to the substitution of Glu³ with Arg³ and the addition of a 13-amino-acid N-terminal extension peptide, both of which reduce binding to IGF-binding proteins (IGFBPs) and increase the in-vitro bioavailability of the free peptide. IGF-1 LR3 is distinct from DES(1-3) IGF-1, which is a truncated variant missing the first three N-terminal residues — the two compounds are not interchangeable in research applications. SPK Pharma India supplies IGF-1 LR3 as a research-grade lyophilized peptide, intended for in-vitro IGF-1 receptor research, cell-based proliferation and differentiation studies, and analytical method development.

Specifications

Research context

IGF-1 LR3 is a well-characterised research tool in IGF-1 receptor (IGF-1R) biology. The IGF-1 receptor is a receptor tyrosine kinase that signals through the PI3K-AKT and MAPK-ERK pathways, with downstream effects on cellular proliferation, survival, and metabolic gene expression. The long-arginine modification reduces binding to the major IGF-binding proteins, which makes the LR3 variant useful in research contexts where the free-peptide receptor-engagement profile is the variable of interest — for example, in cell-based proliferation assays, in studies of receptor internalisation, and in analytical method development for LC-MS quantification.

The disambiguation from DES(1-3) IGF-1 is important: the two variants have different molecular weights, different IGFBP-binding profiles, and different receptor-engagement kinetics, and they are not interchangeable as research comparators. SPK Pharma India does not make therapeutic, clinical, diagnostic, or dosing claims for this product. The compound is supplied strictly for in-vitro research, analytical method development, and reference-standard work.

For researchers new to the compound, the standard analytical reference points are CAS 946870-92-4, the 83-amino-acid backbone, the approximate molecular weight of 9,116.2 g/mol, the lyophilized powder form, and the documented purity threshold (≥99% HPLC). The full amino acid sequence is disclosed on the lot-matched COA and on the product specification sheet.

Packaging and supply

• 1 mg research vial — for method development, receptor-binding assays, and reference-standard qualification. Standard MOQ: 5 vials.
• 2 mg research vial — for ongoing research programmes with higher per-assay demand. Standard MOQ: 2 vials.
• Bulk pack — on application, for annual supply contracts and recurring orders.

Distributor pricing is available on application. Annual supply contracts with scheduled recurring dispatch are available for repeat buyers. Lead time for in-stock SKUs is typically 5 business days from purchase order confirmation; lead time for scheduled production is typically 4 to 6 weeks.

Quality and documentation

Every lot of IGF-1 LR3 ships with a lot-matched Certificate of Analysis documenting identity (mass spectrometry and amino acid analysis), purity (HPLC), appearance, lot number, and synthesis batch reference. A representative sample of every lot is independently verified by a third-party analytical laboratory before release. MSDS is supplied with every shipment. The COA template, the lot-traceability workflow, and the third-party verification scope are documented on the Quality page.

Storage and handling

• Store at -20°C in the original sealed container.
• Protect from light and moisture.
• Allow the sealed container to reach room temperature before opening, to avoid condensation.
• Reconstitute in sterile, low-endotoxin research-grade water or in a mild buffer at the working concentration required by the assay.
• Do not refreeze once reconstituted; aliquot and store at working concentration.
• For protein work, avoid vigorous vortexing; allow gentle dissolution to minimise aggregation.

Shipping

IGF-1 LR3 is shipped lyophilized in sealed vials within temperature-validated packaging. International lanes are routed through dedicated life-science logistics partners with cold-chain handling. Standard dispatch is within 5 business days of purchase order confirmation. SPK Pharma India ships to the United States, the European Union, the United Kingdom, Canada, MENA, APAC, and LATAM. Full export documentation, including commercial invoice, packing list, certificate of origin, COA, and MSDS, is included with every shipment. Destination-specific documentation is supported on request.

Compliance

This product is supplied for research use only. It is not a drug, not a finished dosage form, and not approved for human or veterinary administration. SPK Pharma India does not make therapeutic, clinical, diagnostic, or dosing claims for this product. The buyer is responsible for end-use classification in the destination jurisdiction and for ensuring that downstream handling is consistent with research-use-only protocols.

Lead form CTA

To request a wholesale quote for IGF-1 LR3, contact the trade desk with the subject line "IGF-1 LR3 wholesale quote" and your company details, expected volume, and destination country. Distributor pricing is available on application. The desk responds within one business day.

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